Hemorrhagic Diathesis
Immune thrombocytopenic purpura (ITP) • Also called idiopathic thrombocytopenic purpura • Autoimmune disorder with production of anti-platelet antibody causing destruction of platelet – Primary or idiopathic( absence of any known risk factors ) – Secondary • Primary – Acute – Chronic- more common • Secondary – Systemic lupus erythematosus – AIDS – After viral infection – drug therapy Chronic ITP • Adult women younger than age 40 years • F:M= 3:1 • Insidious onset • Bleeding into skin and mucosal surfaces • Petechiae, ecchymoses • H/O nosebleeds, bleeding from gums, hemorrhage into soft tissues from minor trauma • May present with melena, hematuria or excessive menstrual flow • Subarachnoid hemorrhage and intracerebral hemorrhage: Serious consequences