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Iron Metabolism

Iron   metabolism Curriculum •       List the iron containing haeme and non-haeme   proteins   and describe their functions •       Describe the intestinal absorption of iron and distribution kinetics in the body •       Describe the process of haeme biosynthesis and catabolism •       Describe iron deficiency anaemia and acute intermittent porphyria •       Describe the diagnostic test for iron states (serum iron, serum iron binding capacity, serum ferritin) •       Describe and classify porphyria •       Describe the causes, diagnosis and management of porphyria Heme containing proteins & enzymes Hemoglobin: transport of oxygen in blood Myoglobin: storage of oxygen in muscle Cytochrome c: involvement in oxygen transport chain Catalase/Peroxidase: antioxidant enzym...

Chronic Myeloproliferative Disease

Polycythemia, or erythrocytosis, is an increase in the blood concentration of red cells, which usually correlates with an increase in the hemoglobin concentration •        Classification –       Relative –       Absolute •        Relative polycythemia –       Hemoconcentration caused by a decrease in plasma volume –       Results   from any cause of dehydration •          Water deprivation •          Prolonged vomiting •        Diarrhea •        Excessive use of diuretics •        Absolute polycythemia –       Increase in the total red cell mass –       Primary: increase in red cell mass...

Vascular System

ARTERIAL SYSTEM Thoracic Aorta •        T4 – T12 •        Branches –       Pericardial –       Bronchial 2 left bronchial –       Esophageal 4-5 –       Mediastinal –       Posterior intercostal for lower 9 ICS                               upper 2 from costo-cervical trunk –       Superior phrenic –       Subcostal Abdominal Aorta •        Extent – aortic   hiatus T12 – L4 ( line joining highest point of iliac crest) •        Branches –       Visceral •        unp...

Neoplastic Proliferation of WBC

White blood cells ·          Myeloid –         Myeloblast –         Promyelocyte –         Myelocyte –         Metamyelocyte –         Band –         Neutrophil,eosinophil, basophil •           Lymphoid –         Lymphocyte (B and T) and plasma cells –         Neoplastic proliferation of white cells Classification according to the origin of tumor cells: –         Lymphoid neoplasms •           Lymphocytic Leukemia •           Lymphoma (Hodgkin and non Hodgkin) •  ...